I think the question is or at least the one that comes to m…

I think the question is or at least the one that comes to mind is “ who are you?” Or, “who am I”
That (who we are) theoretically could be the same thing in and outside of a so-called simulation.
Personally, I don’t look at it as one begets meaninglessness, and the other meaning. It’s all in one’s perception of a so called simulation.
And I like your take that we choose meaning. Absolute agreement with that!