**Supporting Evidence:** - Bone cells (osteocytes) do have …

**Supporting Evidence:**
- Bone cells (osteocytes) do have mechanoreceptors that respond to mechanical loading
- The obesogen research shows the body does increase fat storage in response to toxins
- The weighted vest study showed durable metabolic changes that persisted after removal
- Astronauts in zero gravity experience both bone loss and metabolic changes
- Weight-bearing exercise affects both bone density and metabolism