So it seems like you can increase tolerance through trainin…

ruthheasman ·

So it seems like you can increase tolerance through training. Migraines may begin when reduced CO2 production (breathlessness) causes blood vessels to constrict. The resulting low oxygen/brain energy from hyperventilation (losing too much CO2) causes nitric oxide and lactate release, causing blood vessels to dilate and create a spasming effect as the brain attempts to restore blood flow.
"A response to stimulation is the production of more energy, with a proportional increase of oxygen and sugar consumption by the stimulated tissue; this produces more carbon dioxide, which enlarges the blood vessels in the area, providing more sugar and oxygen. If the irritation becomes destructive, efficiency is lost: oxygen is either consumed wastefully, causing blueness of the tissue (assuming circulation continues; blueness can aiso indicate bad circulation), or is not consumed, causing redness of the tissue. As more sugar is consumed in compensation, lactic acid also enlarges the blood vessels."
- Ray Peat PhD, Nutrition For Women

Nitric oxide has been linked to migraine for over 150 years, ever since the discovery of nitroglycerin. Nitroglycerin works for chest pain by creating nitric oxide, but in doing so, it also triggers migraine attacks in susceptible individuals. Our work shows that this may happen through peroxynitrite that is created when nitric oxide reacts with other substances within the body, and not by nitric oxide itself. - Dr. Gregory Dussor
https://www.sciencedirect.com/science/article/abs/pii/S0076687914001037
For the past 7 or so years, I’ve used molecular hydrogen as a way to detoxify hydroxyl radicals (OH) and peroxynitrite intracellularly, which lowers oxidative stress systemically - something I struggle with due to systemic inflammation caused by rheumatoid arthritis. I drink hydrogen rich water (made by electrolysis) and take a Megahydrate daily to increase my H2 levels. It gives more resilience during exercise.
https://molecularhydrogeninstitute.org/scientific-studies/