One can extend out one of the horizontal rows of the Tonnet…
One can extend out one of the horizontal rows of the Tonnetz indefinitely, to form a never-ending sequence of perfect fifths: F-C-G-D-A-E-B-F#-C#-G#-D#-A#-E#-B#-Fx-Cx-Gx- (etc.) Starting with F, after 12 perfect fifths, one reaches E#.