2. **Potential Issues**: Although vitamin B12 is water-solu…

2. **Potential Issues**: Although vitamin B12 is water-soluble and the body usually excretes excess through urine, prolonged intake of high amounts might:
- Cause acne or rosacea flare-ups in some individuals due to the body's attempt to get rid of the excess through the skin.
- Interfere with absorption of other vitamins, particularly B6.
- In some rare cases, people might develop a resistance to high doses of B12, which can make the body less responsive to its effects.